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. 2026 Jan 28;16:1736033. doi: 10.3389/fendo.2025.1736033

Figure 2.

Network diagram illustrating protein interactions with CDC42 at the center. Surrounding nodes include BAIAP2, CDC42EP1, PAK4, RHOB, ROCK1, PAK2, CDC42EP5, and CDC42EP2. Each node is linked by colored lines, indicating interaction pathways. Network diagram illustrating protein interactions with CDC42 at the center. Surrounding nodes include BAIAP2, CDC42EP1, PAK4, RHOB, ROCK1, PAK2, CDC42EP5, and CDC42EP2. Each node is linked by colored lines, indicating interaction pathways. Network diagram illustrating protein interactions with CDC42 at the center. Surrounding nodes include BAIAP2, CDC42EP1, PAK4, RHOB, ROCK1, PAK2, CDC42EP5, and CDC42EP2. Each node is linked by colored lines, indicating interaction pathways. Network diagram illustrating protein interactions with CDC42 at the center. Surrounding nodes include BAIAP2, CDC42EP1, PAK4, RHOB, ROCK1, PAK2, CDC42EP5, and CDC42EP2. Each node is linked by colored lines, indicating interaction pathways. Network diagram illustrating protein interactions with CDC42 at the center. Surrounding nodes include BAIAP2, CDC42EP1, PAK4, RHOB, ROCK1, PAK2, CDC42EP5, and CDC42EP2. Each node is linked by colored lines, indicating interaction pathways. Network diagram illustrating protein interactions with CDC42 at the center. Surrounding nodes include BAIAP2, CDC42EP1, PAK4, RHOB, ROCK1, PAK2, CDC42EP5, and CDC42EP2. Each node is linked by colored lines, indicating interaction pathways.

String analysis of the RHO GTPases network components (GTPases + effectors) identified in MEred, MEbrown and MEpurple modules. Note the central functional position occupied by CDC42. Colored nodes: query proteins and first shell of interactors. Network diagram illustrating protein interactions with CDC42 at the center. Surrounding nodes include BAIAP2, CDC42EP1, PAK4, RHOB, ROCK1, PAK2, CDC42EP5, and CDC42EP2. Each node is linked by colored lines, indicating interaction pathways. line: Curated database. Network diagram illustrating protein interactions with CDC42 at the center. Surrounding nodes include BAIAP2, CDC42EP1, PAK4, RHOB, ROCK1, PAK2, CDC42EP5, and CDC42EP2. Each node is linked by colored lines, indicating interaction pathways. line: Experimentally determined. Network diagram illustrating protein interactions with CDC42 at the center. Surrounding nodes include BAIAP2, CDC42EP1, PAK4, RHOB, ROCK1, PAK2, CDC42EP5, and CDC42EP2. Each node is linked by colored lines, indicating interaction pathways.Network diagram illustrating protein interactions with CDC42 at the center. Surrounding nodes include BAIAP2, CDC42EP1, PAK4, RHOB, ROCK1, PAK2, CDC42EP5, and CDC42EP2. Each node is linked by colored lines, indicating interaction pathways.Network diagram illustrating protein interactions with CDC42 at the center. Surrounding nodes include BAIAP2, CDC42EP1, PAK4, RHOB, ROCK1, PAK2, CDC42EP5, and CDC42EP2. Each node is linked by colored lines, indicating interaction pathways. lines: Predicted interactions.