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. 2026 Jan 28;16:1736033. doi: 10.3389/fendo.2025.1736033

Figure 5.

Two scatter plots with a trend line and shaded confidence interval. The x-axis is labeled “z.value,” and the y-axis is labeled “Estimate.” Data points are labeled with identifiers like MIR3643 and MIR6742, with varying colors and positions across both plots.

Panels (a, b) Linear regression between Lipid metabolism genes and miRNAs. Using mirTarRnaSeq we predicted linear regression between miRNAs in the MEgreen+METurquoise modules (positively correlated with cbFFA) with genes involved in Lipid metabolism contained in the MEgreen module (negatively correlated with cbFFA). All the miRNA-gene interactions reported have a p-value <0.05. Panel (A), upper CDS1; Panel (B), lower SMUG1. Azure: miR23b. This gene is known to be overexpressed in obesity; Red: miR-196b, this miRNA is considered a master regulator of adipogenesis; Pink: miRNA-138 this miRNA is closing involved in targeting adipogenesis Lipoprotein Lipase, a key lipogenic enzyme in ahMSCs. The datasets for this study can be found in the Harvard Dataverse: https://doi.org/10.7910/DVN/LOIDQS.