Table 2.

Reactome analysis of the coding-gene module “MEred’ in placentas obtained from mothers affected by obesity.

System	Pathway	Significant genes	P-value	FDR
Signal Transduction	RHOQ GTPase cycle; CDC42 GTPase cycle; RHOj GTPase cycle; RHOG GTPase cycle; RHOD GTPase cycle; RAC1 GTPase cycle; Competing Endogenous RNAs (ceRNAs); Negative Regulation of TCF-dependent signaling by DVL-interacting proteins.	CDC42BPB, RAB7A, CDC42EP4, RHOB ARHGAP17-30-21, ARHGEF11-12-5, PAK4, DOCK1-8,	0.00049	0.86
Gene Expression	Post-Transcriptional silencing by small RNAs.; Regulation of NPAS4 mRNA Translation; RNA Polymerase II Transcription Termination; Small Interfering RNA (siRNA) Biogenesis; Regulation of Endogenous retro elements by Piwi-interacting RNAs (piRNAs)	AGO1, TNRC6A	0.0014	0.99
Cell Cycle	Nuclear Pore Complex (NPC) Disassembly;	NUP98-188-214, POM121C-121	0.0027	0.99
Disease	Defective TPR may confer susceptibility towards Thyroid papillary carcinoma (TPC); Loss of MECP2 binding ability to 5mC-DNA; Disorders of Developmental Biology; Disorders of SNC;	MECP2, SIN3A, NCOR1	0.003	0.99
Metabolism	Regulation of Glucokinase Regulatory Protein	NUP98-188-214, POM121C-121	0.008	0.99
Cell-cell Communication	Regulation of CDH11 mRNA translation by microRNAs	AGO1, TNRC6A	0.01	0.99

Using Reactome, an open source, peer-reviewed pathway database, we analyzed genes contained in the MEred module positively correlating with maternal leptin in the WGCNA analysis. The p-value and FDR reported belong to the pathway with the most significant p-value listed in that specific system. The pathways reported are all the pathways that presented p-value <0.05 in the Reactome analysis for all the genes listed in Mered.