Table 3.

Reactome analysis of the coding-gene module “MEpurple” in placentas obtained from mothers affected by obesity.

System	Pathway	Significant genes	P-value	FDR
Immune System	Neutrophil Degranulation; Endosomal/Vacuolar Pathway; IL-21 signaling;	HLAB-C, MMP9, IGFR2, MAPK1, CTSA, SLC2A3, TMC6, TSPAN9-14	0.0004	0.13
Signal Transduction	CDC42 GTPase cycle; RHOQ; RAC1; RHOC; RHOB; RHOJ; RAC3; RAC2; RHOA	CDC42EP1-3-5, ARHGAP1-33, ARHGDIA, ARHGEF10-25, GIT1-2, ROCK1, GIT1-2, FNBP1	0.0002	0.13
Neuronal System	Tandem of pore domain in a weak inwardly rectifying K+ channels;	KCNK6-7	0.008	0.98
Programmed cell Death	CASP8 activity is inhibited	FAS, CFLAR	0.01	0.98
Developmental Biology	SEma4D induced cell migration and growth-cone collapse; Sema4D in semaphoring signaling;	MYH9, MYL9, SEMA4D	0.01	0.98
Extracellular Matrix Organization	Elastic Fiber Formation; Molecules Associated with elastic fibers;	TGFB3, LOXL2, BMP2, EFEMP2	0.012	0.98
Metabolism of proteins	Post-translational protein phosphorylation	IGFBP3-7, SPARC, TIMP1, APOE	0.015	0.98
Disease	Defective NEU1 causes Sialidosis	GLB1L, CTSA	0.03.2	0.98

Using Reactome, an open source, peer-reviewed pathway database, we analyzed genes contained in the MEpurple module positively correlating with cbFFA in the WGCNA analysis. The p-value and FDR reported belong to the pathway with the most significant p-value listed in that specific system. The pathways reported are all the pathways with a p-value <0.05 in the Reactome analysis for all the genes listed in MEpurple.