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. 2005 Nov 23;33(20):e178. doi: 10.1093/nar/gni175

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© The Author 2005. Published by Oxford University Press. All rights reserved

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Mutant library and targets (a) Localization of the area of the binding interface (bottom view) chosen for randomization (green) and interacting base pairs (−3, orange; −4, pink; −5, magenta). (b) Zoom showing residues 44, 68 and 70 chosen for randomization (green), D75 (red) and interacting base pairs (−3, orange; −4, pink; −5, magenta). (c) Sequences of the target used for selection and screening. C1234, wild-type target C1221; and C4334, palindromic site derived from C1234. H1221 and H4334, palindromic sites related to C1221. Boxes highlight bases not found in sites C1221 or C4334.