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. Author manuscript; available in PMC: 2026 Feb 12.
Published in final edited form as: ACS Chem Biol. 2025 Oct 20;20(11):2630–2636. doi: 10.1021/acschembio.5c00473

Figure 2.

Figure 2.

The ceiling effect of CFTR modulators. A-C) Incubation with increasing concentrations of CFTR-modulators (ETI) (measurements taken 48 hrs. after modulator treatment) does not lead to further increases in secretory H14CO3− flux to the ASL or increases in ASL pH in CF airway epithelia in comparison to the lowest dose of ETI tested here. D) 48-hour treatment with either ETI/forskolin or AmB increases ASL pH in CuFi-1 epithelia; Additive effects are observed when these two treatments are combined. Student T-test used for statistical analysis: ns not significant, *P≤0.05, **P ≤0.01, ***P ≤0.001, **** P ≤0.0001.