Fig. 2.

CSF proteins from the differential diagnostic panel are dysregulated across groups.

Protein concentrations in CSF from (A) ITGB2, (B) DDC, (C) THOP1, (D) ENO2, and (E) MMP7 were sequentially measured either on the custom PEA or the Ella platform. (F) Forest plots display the area under the curve (AUC) of the Receiver operating characteristic analysis from our CSF differential diagnostic panel discriminating different clinical groups. Abbreviations: CON, controls; MCI-Aβ+, mild cognitive impairment with amyloid pathology; AD, Alzheimer’s disease; DLB, dementia with Lewy bodies; FTD, Frontotemporal dementia; ITGB2, integrin subunit beta 2; DDC, dopa decarboxylase; THOP1, thimet oligopeptidase; ENO2, enolase 2; MMP7, Matrix metallopeptidase 7; NPX, normalized protein expression. # p < 0.05 (nominal significance), * q < 0.05, ** q < 0.01, *** q < 0.001 (significant after post-hoc analysis)