ABCA1	ATP-binding cassette subfamily A1
ABCG1	ATP-binding cassette subfamily G1
Acetyl-CoA	Acetyl coenzyme A
Akt	Ak strain transforming
ANXA6	Annexin A6
APC	Adenomatous polyposis coli
APOE	Apolipoprotein E
CD8 + T	CD8-positive T lymphocyte
COPII	Coat protein complex II
CP24	24-dehydrocholesterol reductase (DHCR24)
CRISPR	Clustered regularly interspaced short palindromic repeats
cryo-EM	Cryo-electron microscopy
DHCR24	(Standard for CP24) 24-dehydrocholesterol reductase
DMAPP	Dimethylallyl pyrophosphate
DNA	Deoxyribonucleic acid
E-cadherin	Epithelial cadherin
E2F2	E2F transcription factor 2
EEF2K	Eukaryotic elongation factor 2 kinase
EGFR	Epidermal growth factor receptor
EMT	Epithelial–mesenchymal transition
ER	Endoplasmic reticulum
ERK	Extracellular signal-regulated kinase
FOXO1	Forkhead Box O1
GGPP	Geranylgeranyl pyrophosphate
GOBP	Gene ontology biological process
GPX4	Glutathione peroxidase 4
GTPase	Guanosine triphosphatase
HDL	High-density lipoprotein
HER2	Human epidermal growth factor receptor type 2
Hh	Hedgehog signaling protein
HIF-1α	Hypoxia-inducible factor-1 α
HMG-CoA	3-hydroxy-3-methylglutaryl coenzyme A
HMGCR	3-hydroxy-3-methylglutaryl-CoA reductase
INSIG	Insulin-induced gene protein
IPP	Isopentyl pyrophosphate
KRAS	Kirsten rat sarcoma viral oncogene homolog
LAMP	Lysosome-associated membrane protein
LCAT	Lecithin–cholesterol acyltransferase
LDL	Low-density lipoprotein
LDLR	Low-density lipoprotein receptor
LE/Lys	Late endosome/lysosome
LOX1	Lectin-like oxidized low-density lipoprotein receptor-1
LXR	Liver X receptor
LXRE	Liver X-responsive elements
LXRα	Liver X receptor α (NR1H3)
LXRβ	Liver X receptor β (NR1H2)
MEK	Mitogen-activated protein kinase kinase
mSREBP	Membrane-bound sterol regulatory element-binding protein
mTOR	Mechanistic target of rapamycin
mTORC1	Mechanistic target of rapamycin complex 1
MZF1	Myeloid zinc Finger 1
NBD	Nucleotide-binding domains
NF-κB	Nuclear factor kappa-light-chain-enhancer of activated B cells
NPC1	Niemann–Pick type C1 protein
NPC2	Niemann–Pick type C2 protein
NPs	Nanoparticles
NR1H2	Nuclear receptor subfamily 1 group H member 2 (LXRβ)
NR1H3	Nuclear receptor subfamily 1 group H member 3 (LXRα)
nSREBP	Nuclear sterol regulatory element-binding protein
p53	Tumor protein 53
PCSK9	Proprotein convertase subtilisin/kexin type 9
PD-1	Programmed cell death protein 1
PI3K	Phosphoinositide 3-kinase
QIBC	Quantitative imaging-based cytometry
RAB7	Ras-related in brain protein 7
RAF	Rapidly accelerated fibrosarcoma
RAS	Rat sarcoma virus
RCT	Reverse cholesterol transport
RhoA	Ras homolog family member A
RXR	Retinoid X receptor
S1P	Site-1 protease
S2P	Site-2 protease
SCAP	SREBP cleavage-activating protein
siRNA	Small interfering RNA
SKP2	S-phase kinase-associated protein 2
SMO	Smoothened receptor
SOAT1	Sterol O-acyltransferase 1
SQLE	Squalene epoxidase
SQS	Squalene synthase
SR-B1	Scavenger receptor class B type 1
SRE	Sterol regulatory element
SREBP	Sterol regulatory element-binding protein
SREBP2	Sterol regulatory element-binding protein 2
SRF	Serum response factor
SSD	Sterol-sensing domain
STARD3	StAR-related lipid-transfer domain-containing protein 3
TAZ	Transcriptional co-activator with PDZ-binding motif
TBC1D5	TBC1 domain family member 5
TCR	T cell receptor
TFCP2	Transcription factor CP2
TMD	Transmembrane domains
VLDL	Very low-density lipoprotein
VLDLR	Very low-density lipoprotein receptor
WD	WD-repeat domain
XBP1	X-box binding protein 1
YAP	Yes-associated protein