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. 2026 Feb 6;27(3):1601. doi: 10.3390/ijms27031601
MASLD Metabolic dysfunction-associated liver disease
MASH Metabolic dysfunction-associated steatohepatitis
HCC hepatocellular carcinoma
PNPLA3 patatin-like phospholipase domain-containing 3
LDs lipid droplets
ROS oxidative reactive species
mt-ccf mitochondrial DNA fragments
HEPs hepatocytes
PZ Portal zone
CZ Central zone
NPCs non-parenchymal cells
WT wild-type
T2DM Type 2 Diabetes Mellitus
H&E Hematoxylin-Eosin
BMI body mass index
ALT alanine aminotransferase
UMI Unique Molecular Identifiers
HSCs hepatic stellate cells
GO Gene Ontology
TCA citrate cycle
NAS NAFLD Activity Score
TM6SF2 transmembrane 6 superfamily member 2
MBOAT7-TMC4 Membranebound O-acyltransferase domain containing 7-transmembrane channel-like 4
HPCs hepatic progenitor cells
HpSC hepatic stem cells/progenitor cell