MSU	monosodium urate
NLRP3	NOD-like receptor thermal protein domain associated protein 3
ROS	reactive oxygen species
IL-1β	interleukin-1β
NETs	neutrophil extracellular traps
TLR4	Toll-like receptors 4
MYD88	Myeloid Differentiation Primary Response 88
ASICs	acid-sensing ion channels
SYK	Spleen tyrosine kinase
MRGPRX2	Mas-related G protein-coupled receptor member X2
STING	stimulator of interferon genes
ASC	apoptosis-associated speck-like protein containing a CARD
NETosis	neutrophil extracellular trap
MPO-HOCl	myeloperoxidase-hypochlorous acid
NAD	Nicotinamide Adenine Dinucleotide
SIRT1	silent information regulator 1
NF-κB	nuclear factor kappa-B
HDACs	histone deacetylases
CD39	Ectonucleoside triphosphate diphosphohydrolase-1
FLSs	Fibroblast-like synoviocytes
SQSTM1/p62	Sequestosome 1
mTORC1	Mechanistic Target of Rapamycin Complex 1
GAS	gout activity score
HDL-C	High density lipoprotein cholesterol
NUMB	NUMB endocytic adaptor protein
ABCG2	ATP binding cassette subfamily G member 2 Gene
TNF-α	tumor necrosis factor-α
IL-6	interleukin-6
H3K4me3	Tri-methylation of lysine 4 on histone H3
H3K27ac	H3 K27 acetylation
ox-LDL	oxidized low-density lipoprotein
hs-CRP	high-sensitivity C-reactive protein
TADs	topologically associating domains
NFIL3	nuclear factor, interleukin 3 regulated Gene
REDD1	Regulated in Development and DNA Damage Response 1
mTOR	mammalian target of rapamycin
MRI	magnetic resonance imaging
RANKL	Tumor necrosis factor ligand superfamily member 11
RANK	Tumor necrosis factor receptor superfamily member 11A
OPG	osteoclastogenesis inhibitory factor
BMP-2	Bone Morphogenetic Protein 2
DECT	Dual Energy Computed Tomography
WNT5A	Wnt family member 5A Gene
TGF-β	Transforming growth factor beta
T2T	treat-to-target
ROS-NLRP3	reactive oxygen species- NOD-like receptor thermal protein domain associated protein 3
MitoQ	Mitoquinone mesylate
PAD4	peptidylarginine deiminase 4
GSK484	peptidyl arginine deiminase 4 inhibitors
AMPK	Adenosine 5′-monophosphate (AMP)-activated protein kinase
MPC	mitochondrial pyruvate carrier
MLT-MLP	macrophage membrane-coated melatonin-loaded liposomes
SUCNR1	succinate receptor
BET	Bromodomain and extraterminal
JQ1	BET protein inhibitor
UMOD	uromodulin
CT	computed tomography
CARD8	caspase recruitment domain family member 8 Gene
TNF	tumor necrosis factor domains
SCFAs	short-chain fatty acids
TGF-β1	Transforming Growth Factor β1
COMP	artilage oligomeric matrix protein