53BP1	TP53-binding protein 1
5-FU	5-fluorouracil
9-1-1	RAD9-RAD1-HUS1 complex
AML	acute myeloid leukemia
AMPK	AMP-activated protein kinase
ARID1A	AT-rich interactive domain-containing protein 1A
ASIR	age-standardized incidence rate
ASMR	age-standardized mortality rate
ATM	ataxia-telangiectasia mutated kinase
ATP8B1	ATPase phospholipid transporting 8B1
ATR	ataxia telangiectasia and rad3-related
ATRIP	ATR-interacting protein
BAX	BCL2 associated X, apoptosis regulator
BCL-2	B-cell lymphoma 2
BCL-XL	B-cell lymphoma-extra large
BMI	body mass index
BRCA1/2	breast cancer type 1/2 susceptibility protein
CAFs	cancer-associated fibroblasts
CBP/p300	CREB-binding protein (CBP) and its paralog p300
CCL2	C–C motif chemokine ligand 2
CCL3	C–C motif chemokine ligand 3
CCL5	C–C motif chemokine ligand 5
CD44	Cluster of Differentiation 44
CDC25	cell division control 25 phosphatases
CDK	cyclin-dependent kinases
CDKN2A	cyclin-dependent kinase inhibitor 2A
cGAS–STING	GMP-AMP synthase–stimulator of interferon genes
CHK1	checkpoint kinase 1
CHK2	checkpoint kinase 2
CHOP	C/EBP homologous protein
CMTM6	CKLF-like MARVEL transmembrane domain-containing protein 6
CRISPR	clustered regularly interspaced short palindromic repeats
CRISPR-Cas9	Clustered Regularly Interspaced Short Palindromic Repeats–CRISPR-associated protein 9
CtBP	C-terminal binding protein
CtIP	CtBP interacting protein
CXCL10	C–X–C motif chemokine ligand 10
DALYs	disability-adjusted life years
DDR	DNA damage response
DNA-PK	DNA-dependent protein kinase
DNA-PKcs	DNA-dependent protein kinase catalytic subunit
dNTP	deoxynucleotide triphosphate
DOR	duration of response
DSBR	double-strand DNA break repair
DSBs	DNA double-strand breaks
EcDNA	extrachromosomal DNA
ecDTx	ecDNA-directed therapy
EHMT2	histone methyltransferase G9a
EMT	epithelial-to-mesenchymal transition
ER	endoplasmic reticulum
ERK	extracellular signal-regulated kinase
ETAA1	Ewing tumor-associated antigen 1
FOL	folinic acid
GRP78	glucose-regulated protein 78
HER2	human epidermal growth factor receptor 2
HNSCC	head and neck squamous cell carcinoma
HR	homologous recombination
HRD	homologous recombination deficiency
ICGC	International Cancer Genome Consortium
IFN-1	type I interferon
IHC	Immunohistochemistry
IMPaCT	The Individualized Molecular Pancreatic Cancer Therapy
IRE	irreversible electroporation
IRI	irinotecan
KAP1	KRAB-associated protein 1
KO	knockout
KPC	genetically engineered mouse model with Kras^G12D, Trp53^R172H, and pancreas-specific Cre recombinase
LIG4	ligase IV
LIGIII	DNA ligase III
MDC-1	mediator of DNA damage checkpoint protein 1
mDDRi	multi-DDR interference
MDM2	mouse double minute 2 homolog
MDS	myelodysplastic syndromes
MDSCs	myeloid-derived suppressor cells
MOF	metal–organic framework
MRN	MRE11-RAD50-NBS1 complex
MTD	maximum-tolerated dose
nal-IRI	liposomal irinotecan
NBS1	Nibrin
NGS	next-generation sequencing
NHEJ	non-homologous end joining
OS	overall survival
OXA	oxaliplatin
P21	cyclin-dependent kinase inhibitor 1A
PALB2	partner and localizer of BRCA2
PAR	poly(ADP-ribose)
PARP	poly (ADP-ribose) polymerase
PARPi	PARP inhibitor
PCNA	proliferating cell nuclear antigen
PD-1/PD-L1	programmed cell death protein 1/programmed death-ligand 1
PDAC	pancreatic ductal adenocarcinoma
PDX	patient-derived xenograft
PFS	progression-free survival
PK	Pharmacokinetics
PLK1	Polo-like kinase 1
PNKP	polynucleotide kinase/phosphatase
POLB	DNA polymerase β
pRB	retinoblastoma protein
PUMA	p53 up-regulated modulator of apoptosis
RAD17	replication factor C (RFC)-related RAD17
RAD51	DNA repair protein RAD51 homolog/RAD51 homolog 1
RAD54L	DNA repair and recombination protein RAD54-like
RCC	renal cell carcinoma
RE	reversible electroporation
RecQ1	ATP-dependent DNA helicase Q1
RIF1	replication timing regulatory factor 1
RNF4	ring finger protein 4
RNF8	ring finger protein 8
RNF168	ring finger protein 168
RNR	ribonucleotide reductase
ROS	reactive oxygen species
RP2D	recommended phase II dose
RPA	replication protein A
RRM2	ribonucleotide reductase M2 subunit
RS	replication stress
S-1	tegafur, gimeracil (CDHP), and oteracil potassium (Oxo)
SCLC	small cell lung cancer
siRNA	small interfering RNA
SMAD4	SMAD family member 4
SNPs	single-nucleotide polymorphisms
SRC	SRC proto-oncogene, non-receptor tyrosine kinase
SSBR	single-strand DNA break repair
SSBs	single-strand breaks
ssDNA	single-stranded DNA
SWI/SNF	SWItch/Sucrose Non-Fermentable
TAMs	M2-like tumor-associated macrophages
TBK1	TANK-binding kinase 1
TCR	T cell receptor
TEAEs	treatment-emergent adverse events
TIP60	Tat-interactive protein 60 kDa
TMB	tumor mutation burden
TME	tumor microenvironment
TNBC	triple-negative breast cancer
TOPBP1	DNA topoisomerase 2-binding protein 1
TP53	cellular tumor antigen P53
TREGs	regulatory T-cells
TYMS	thymidylate synthase
UPR	unfolded protein response
WEE1	G2 checkpoint kinase
XRCC1	X-ray repair cross-complementing protein 1