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. 2026 Jan 27;31(3):450. doi: 10.3390/molecules31030450
FXR Farnesoid X receptor
NR Nuclear receptor
BA Bile acid
CDCA Chenodeoxycholic acid
CYP7A1 Cholesterol 7α-hydroxylase
SHP Small heterodimer partner
FGF Fibroblast growth factor
TGR5 Transmembrane G protein-coupled receptor 5
PBC Primary biliary cholangitis
MASH Metabolic-dysfunction-associated steatohepatitis
MASLD Metabolic-dysfunction-associated steatotic liver disease
LDL Low-density lipoprotein
UDCA Ursodeoxycholic acid
T2DM Type 2 diabetes mellitus
PPAR Peroxisome proliferator-activated receptor
PXR Pregnane X receptor
RXR Retinoid X receptor
AR Androgen receptor
AF2 Activation function 2
RP Relative potency
HDL High-density lipoprotein
TR-FRET Time-resolved fluorescence resonance energy transfer
Luc Luciferase reporter gene assay
HTS High-throughput screening
SAR Structure–activity relationship
VDR Vitamin D receptor
MSC Mesenchymal stem cell
LBD Ligand-binding domain
SPA Scintillation proximity assay
GPBAR1 G protein-coupled bile acid receptor 1
LXR Liver X receptor
LTA4H Leukotriene A4 hydrolase
FABP1 Intestinal fatty acid binding protein 1
URAT1 Urate transporter 1
sEH Soluble epoxide hydrolase
HSD17B13 17-β-hydroxysteroid dehydrogenase 13
LIFR Leukemia inhibitory factor receptor
CDK Cyclin-dependent kinase
Gly-MCA Glycine-β-muricholic acid
HFD High-fat diet
Asbt Apical sodium-dependent bile acid transporter
RLM Rat liver microsome
MLM Mouse liver microsome
SMRT Silencing mediator of retinoic acid and thyroid hormone receptor
NcoR1 Nuclear receptor corepressor 1
MW Molecular weight
Fex Fexaramine