| BBB | Blood–brain barrier |
| BMEC | Brain microvascular endothelial cells |
| CNS | Central nervous system |
| MAD | Multiple ascending dose |
| MoA | Mechanism of action |
| MS | Multiple sclerosis |
| MS TreatSim | Multiple Sclerosis Treatment Simulator |
| QSP | Quantitative systems pharmacology |
| RRMS | Relapsing–remitting multiple sclerosis |
| SAD | Single ascending dose |
| SoC | Standard of care |
| TEER | Transendothelial electrical resistance |
| TJP | Tight junction protein |
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