18-MC	18-Methoxycoronaridine
AE	Adverse event
α	Level of statistical significance
AMPA	α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA)
BDNF	Brain-derived neurotrophic factor
cAMP	Cyclic adenosine monophosphate
CDT	Comissão de Dissuasão da Toxicodependência (Drug Addiction Dissuasion Commission)
CID-11	Classificação Estatística Internacional de Doenças e Problemas Relacionados com a Saúde, 11.ª edição (International Classification of Diseases, 11th Revision—ICD-11)
CoA	Certificate of Analysis
CREB	cAMP response element-binding protein
DA	Dopamine
DAT	Dopamine transporter
DMN	Default mode network
D2	Dopamine D2 receptor
DSM-5	Diagnostic and Statistical Manual of Mental Disorders
EAG	Serious adverse event
ECG	Electrocardiogram
EMA	European Medicines Agency
EMCDDA	European Monitoring Centre for Drugs and Drug Addiction
ENLCD	Estratégia Nacional de Luta Contra a Droga (National Drug Strategy)
FDA	Food and Drug Administration
FFUC	Faculdade de Farmácia da Universidade de Coimbra (Faculty of Pharmacy, University of Coimbra)
GABA	Gamma-aminobutyric acid
GABA-A	Gamma-aminobutyric acid receptor A
GCP	Good Clinical Practice
GDNF	Glial cell line-derived neurotrophic factor
GITA	Global Ibogaine Therapy Alliance
HCl	Ibogaine hydrochloride
ICH	International Council for Harmonisation
IPN	Interpeduncular nucleus
ISRS	Inibidores seletivos da recaptação da serotonina (Selective serotonin reuptake inhibitors—SSRIs)
ITT	Intention-To-Treat
Ki	Inhibition constant
KOR	κ-Opioid receptor
MAPK/ERK	Mitogen-activated protein kinase/Extracellular signal-regulated kinase
MHb	Medial habenula
MOR	µ-Opioid receptor
mTOR	Mammalian target of rapamycin (Alvo da rapamicina em mamíferos)
NAc	Nucleus accumbens
nAChR	Nicotinic acetylcholine receptor
NMDA	N-Methyl-D-aspartate receptor
NSP	Novas substâncias psicoativas (New psychoactive substances—NPS)
OMS	Organização Mundial da Saúde (World Health Organization—WHO)
PFC	Prefrontal cortex
PI3K/Akt	Phosphatidylinositol 3-kinase/Protein kinase B
PLCγ	Phospholipase C gamma
PPS	Per-Protocol Set
PTA	Purified total alkaloid extract
RGPD	Regulamento Geral de Proteção de Dados (General Data Protection Regulation—EU 2016/679)
RRMD	Redução de riscos e minimização de danos (Risk Reduction and Harm Minimization)
SERT	Serotonin transporter
SNc	Substantia nigra pars compacta
SS	Safety Set
STROBE	Strengthening the Reporting of Observational Studies in Epidemiology
SUD	Substance Use Disorder
TA	Total alkaloid extract
TUS	Transtorno por Uso de Substâncias (Substance Use Disorder)
UNODC	United Nations Office on Drugs and Crime
VTA	Ventral tegmental area
WDR	World Drug Report
WHO	World Health Organization