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. 2026 Jan 30;16:1727445. doi: 10.3389/fonc.2026.1727445

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Copyright © 2026 Huang, Tang, Cao, Li and Zhu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Histological panel of six images showing immunohistochemical staining. (A) HE with purple staining, (B) IDH-1 with blue staining, (C) MLH1 with brown staining, (D) PMS2 with beige tones, (E) MSH2 with blue staining, and (F) MSH6 with similar blue staining patterns. Each image includes cellular and tissue morphology variations, highlighted by different staining intensities. — Pathological pictures of glioblastoma. (A) H&E staining showed the tumor. (B) IDH protein was wild type (20×). (C, D) The immunohistochemistry of MLH1 and PMS2 were positive in the tumor (20×). (E, F) The immunohistochemistry of MSH2 and MSH6 were absent in the tumor (20×).