Table 2.

Proportion of Probands with Specific Cardiac Pathology by Group

	Patent foramen ovale (PFO)	Atrial septal defect (ASD)	Ventricular septal defect (VSD)	Patent ductus arteriosus (PDA)	Bicuspid aortic valve	Aortic root dilatation	Ascending aorta dilation	Tetralogy of Fallot	Structural
Total (SD)	0.11 (0.31)	0.19 (0.39)	0.11 (0.31)	0.08 (0.27)	0.04 (0.18)	0.01 (0.11)	0.02 (0.15)	0.02 (0.15)	0.58 (1)
Males	0.2 (0.4)	0.35 (0.5)	0.25 (0.4)	0.25 (0.4)	0.05 (0.2)	0 (0)	0 (0)	0 (0)	1.1 (1.3)
Females	0.08 (0.3)	0.14 (0.3)	0.06 (0.2)	0.03 (0.2)	0.03 (0.2)	0.02 (0.1)	0.03 (0.2)	0.03 (0.2)	0.42 (0.8)
p value	0.1	0.04*	0.04*	0.02*	0.4	0.2	0.08	0.08	0.02*
NAA15	0.31 (0.5)	0.23 (0.4)	0.23 (0.4)	0.31 (0.5)	0.08 (0.3)	0 (0)	0 (0)	0 (0)	1.15 (1.4)
No NAA15	0.07 (0.3)	0.18 (0.4)	0.08 (0.3)	0.04 (0.2)	0.03 (0.2)	0.01 (0.1)	0.03 (0.2)	0.03 (0.2)	0.47 (0.9)
p value	0.05	0.3	0.1	0.03*	0.3	0.2	0.08	0.08	0.06

	Tricuspid regurgitation	Mitral regurgitation	Pulmonic Regurgitation	Aortic stenosis	Mitral stenosis	Valvular
Total	0.07 (0.26)	0.06 (0.24)	0.02 (0.15)	0.02 (0.15)	0.01 (0.11)	0.19 (0.52)
Males	0.1 (0.3)	0.05 (0.2)	0 (0)	0 (0)	0 (0)	0.15 (0.4)
Females	0.06 (0.2)	0.06 (0.2)	0.03 (0.2)	0.03 (0.2)	0.02 (0.1)	0.2 (0.6)
p value	0.3	0.4	0.08	0.08	0.2	0.3
NAA15	0.08 (0.3)	0.08 (0.3)	0 (0)	0 (0)	0 (0)	0.15 (0.4)
No NAA15	0.07 (0.3)	0.06 (0.2)	0.03 (0.2)	0.03 (0.2)	0.01 (0.1)	0.19 (0.5)
p value	0.4	0.4	0.08	0.08	0.2	0.4

	Hypertrophic cardiomyopathy (HOCM)	Ventricular hypertrophy	Myocardial	Apical cyst
Total	0.07 (0.26)	0.18 (0.38)	0.25 (0.43)	0.01 (0.11)
Males	0.15 (0.4)	0.45 (0.5)	0.6 (0.5)	0.05 (0.2)
Females	0.05 (0.2)	0.09 (0.3)	0.14 (0.3)	0 (0)
p value	0.1	0.003*	0.0003*	0.2
NAA15	0 (0)	0.54 (0.5)	0.54 (0.5)	0 (0)
No NAA15	0.08 (0.3)	0.11 (0.3)	0.19 (0.4)	0.01 (0.1)
p value	0.007*	0.006*	0.02*	0.2

	Persistent left superior vena cava (PLSVC)	Pulmonary hypertension	Pulmonary vessel stenosis	Coronary fistula	Vascular
Total	0.01 (0.11)	0.04 (0.19)	0.07 (0.26)	0.01 (0.11)	0.13 (0.4)
Males	0 (0)	0.16 (0.4)	0.2 (0.4)	0 (0)	0.35 (0.7)
Females	0.02 (0.1)	0 (0)	0.03 (0.2)	0.02 (0.1)	0.06 (0.2)
p value	0.2	0.04*	0.04*	0.2	0.04*
NAA15	0 (0)	0.08 (0.3)	0.23 (0.4)	0 (0)	0.31 (0.6)
No NAA15	0.01 (0.1)	0.03 (0.2)	0.04 (0.2)	0.01 (0.1)	0.1 (0.3)
p value	0.2	0.3	0.08	0.2	0.1

	Bradycardia	Shortened PR	Prolonged QT	Supraventricular tachyarrhythmias (SVT)	Atrial fibrillation	Ventricular fibrillation	Ventricular tachycardia	Electrophysiological
Total	0.06 (0.24)	0.02 (0.15)	0.33 (0.47)	0.06 (0.24)	0.05 (0.21)	0.02 (0.15)	0.04 (0.18)	0.58 (0.79)
Males	0.05 (0.2)	0.05 (0.2)	0.45 (0.5)	0.1 (0.3)	0.15 (0.4)	0.1 (0.3)	0.15 (0.4)	1.05 (1)
Females	0.06 (0.2)	0.02 (0.1)	0.29 (0.5)	0.05 (0.2)	0.02 (0.1)	0 (0)	0 (0)	0.43 (0.7)
p value	0.4	0.3	0.1	0.2	0.06	0.08	0.04*	0.008*
NAA15	0.08 (0.3)	0 (0)	0.54 (0.5)	0 (0)	0.31 (0.5)	0.15 (0.4)	0.08 (0.3)	1.15 (0.9)
No NAA15	0.06 (0.2)	0.03 (0.2)	0.29 (0.5)	0.07 (0.3)	0 (0)	0 (0)	0.03 (0.2)	0.47 (0.7)
p value	0.4	0.08	0.06	0.01*	0.02*	0.08	0.3	0.02*

	Cardiac arrest	Myocardial infarction	Heart failure	Syncopal episode	Dextrocardia	Total
Total	0.09 (0.29)	0.01 (0.11)	0.01 (0.11)	0.04 (0.18)	0.01 (0.11)	1.9 (2.2)
Males	0.35 (0.5)	0.05 (0.2)	0.05 (0.2)	0.1 (0.3)	0.05 (0.2)	3.9 (2.7)
Females	0.02 (0.1)	0 (0)	0 (0)	0.02 (0.1)	0 (0)	1.3 (1.7)
p value	0.003*	0.2	0.2	0.1	0.2	0.0002*
NAA15	0.38 (0.5)	0.08 (0.3)	0 (0)	0.08 (0.3)	0.08 (0.3)	3.9 (2.4)
No NAA15	0.04 (0.2)	0 (0)	0.01 (0.1)	0.03 (0.2)	0 (0)	1.5 (2.0)
p value	0.02*	0.2	0.2	0.3	0.2	0.0003*

*Denotes significance with α < 0.05