Table 2.
Subgroup analysis according to baseline presence of diarrhea
| Variables | Diarrhea group | No Diarrhea group | p-value |
|---|---|---|---|
| N | 7 | 8 | |
| Age, years | 16.0 (14.0 ~ 21.0) | 12.5 (10.3 ~ 22.0) | 0.463 |
| Gender (M/F) | 5/2 | 3/5 | 0.315 |
| Baseline body weight, kg | 35.5 (32.5 ~ 44.1) | 39.2 (29.1 ~ 46.2) | 0.779 |
| Time interval OP to PLE diagnosis, years | 2.5 (1.2 ~ 8.1) | 2.2 (0.6 ~ 7.0) | 0.535 |
| Baseline symptoms | |||
| Stool number (median, IQR) | 3.5 (3.5 ~ 4.25) | 1.5 (1.0 ~ 2.25) | 0.009 |
| Edema, N (%) | 4/7 (57.1%) | 3/8 (37.5%) | 0.619 |
| Ascites, N (%) | 5/7 (71.4%) | 5/8 (62.5%) | 1.000 |
| Laboratory results | |||
| Serum albumin | |||
| Baseline (median, IQR), g/dL | 1.8 (1.7 ~ 2.1) | 2.7 (2.1 ~ 3.5) | 0.076 |
| 6 month f/u (median, IQR), g/dL | 2.4 (2.3 ~ 3.3) | 2.6 (2.5 ~ 3.4) | 0.573 |
| Endpoint (median, IQR), g/dL | 2.2 (2.0 ~ 3.1) | 2.6 (2.2 ~ 3.3) | 0.613 |
| Stool alpha-1 antitrypsin | |||
| Baseline (median, IQR), mg/dL | 220.3 (176.2 ~ 486.5) | 194.1 (56.7 ~ 344.3) | 0.559 |
| 6 month f/u (median, IQR), mg/dL | 75.5 (27.3 ~ 230.7) | 66.2 (40.7 ~ 210.9) | 0.836 |
| Endpoint (median, IQR), mg/dL | 100.3 (38.8 ~ 132.1) | 275.0 (165.3 ~ 396.6) | 0.041 |
Values are number or median, Interquartile range