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Cytotoxicity of peptide 5j-K, 6 c(RGDyK), free MMAE, P1, P2, P3, and P4 in αvβ3 positive cell lines MDA-MB-231 and A549
| Compounds | IC50 (nM) | |
|---|---|---|
| MDA-MB-231 | A549 | |
| 5j-K | >5000 | >5000 |
| P1 (5j-PEG8-VA-MMAE) | 41.3 ± 4.1 | 28.9 ± 4.6 |
| P2 (5j-C8-VA-MMAE) | 31.3 ± 4.3 | 18.5 ± 4.0 |
| P3 (8-PEG8-VA-MMAE) | 72.2 ± 7.9 | 94.1 ± 25.9 |
| 6 [c(RGDyK)] | >5000 | >5000 |
| P4 (6-PEG8-VA-MMAE) | 58.5 ± 3.9 | 37.9 ± 8.4 |
| MMAE | <1.37 | <1.37 |
