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. 2026 Jan 30;17:1714022. doi: 10.3389/fimmu.2026.1714022

Figure 2.

Flow cytometry analysis of CD137, CD25, and CD69 expression. Upper panels show histograms for unstimulated (gray), TAB16, IL-15, and IL-15+TAB16 treatments. Lower panels show bar graphs with significance markers: CD137 shows increased expression with IL-15+TAB16; CD25 shows significant increase with IL-15+TAB16; CD69 also significantly increases, especially with combined treatment. Statistical significance is indicated by asterisks.

TAB16 enhances the activation of IL-15-stimulated NK cells. Enriched NK cells (>90%) were cultured with human Medi-1 (33nM), TAB16 (33 nM), +/– IL-15 (10 ng/ml) for 24 hours. NK cells (CD56+ CD3–) were analyzed for their expression levels of CD25, CD137, and CD69 by flow cytometry. Representative flow plots (top), y-axis = cell number. Cumulative data showing the percent with mean +/– SD. n=6 donors. **p<0.01; ***p<0.001; ****p<0.0001; ns, not significant. Statistical significance was determined by one-way ANOVA with a Tukey post hoc test.