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. 2026 Jan 24;15(2):641–675. doi: 10.1007/s40123-025-01306-9

Table 2.

Study characteristics

Author (year) Design Conflict of interest Inclusion criteria Exclusion criteria Follow-up Numbers of eyes and patients Sex Age
Baldascino et al. (2022) RCSS No NC; CC; No IOD; IOP ≤ 21 mmHg IOP ≥ 21 mmHg; PSC; PP OT; IOS; AXL > 26 mm; abnormal intraocular findings; glaucoma; RL; SD; poor OCT images; PostOp complications 1 Wk 23 eyes (23 patients) NR 75.86 ± 8.85 years
Nourinia et al. (2023) PCS No CS IntraOp or PostOp complications; previous IOS; uveitis; MP; IVI; HTN; DM; DR; CKD; SSI < 6 3 Mo 50 eyes (50 patients)

M: 21

F: 29

66.9 ± 7.7 years
Jia et al. (2021) POS No Age-related cataracts; Age 60–70 years; AXL ≥ 22 mm and ≤ 24 mm; normal IOP; LOCS-N: 2–3 +  DM; HTN; SVD; IOS; OT; RL; high IOP; glaucoma; RD; PostOp anterior chamber inflammation; CE; SSI < 6; excessive artifacts 4 Wk 107 eyes (107 patients)

M: 45

F: 62

63.2 ± 2.7 years
Karabulut et al. (2019) POS No NR MP; ONH pathologies; optic neuropathies; IOP ≥ 21 mmHg; AXL ≤ 20 and ≥ 24 mm; CE; massive cataracts; vasoactive agents use; SD; IOS; SSI ≤ 60 4 Wk 24 eyes (24 patients)

M: 20

F:4

65.4 years (60–70 years)
Liu et al. (2021) PO No

IOP ≤ 21 mmHg; no severe cataracts; no fixation;

no OD; no SD; no previous IOS

NR 3 Mo 58 eyes (47 patients)

M:25

F: 25

66.26 ± 11.92 years
Yu et al. (2018) POS No SSI ≥ 6 Glaucoma; RD; RL 1 Wk 13 eyes (12 patients)

M: 6%

F: 94%

71.2 ± 10.7 years
Zhao et al. (2018) PCS No

NC; CC; no IOD;

IOP ≤ 21 mm Hg;

AXL (20.00–25.00 mm)

PSC; PP; OT; IOS; abnormal intraocular findings; poor OCT images; unstable fixation; IntraOp or PostOp complication 3 Mo 32 eyes (32 patients)

M:14

F:18

66.25 ± 8.54 years
Baldascino et al. (2023) POMC No NC; CC; no IOD; IOP ≤ 21 mmHg IOP ≥ 21 mmHg; PSC; PP; AXL ≥ 26 mm; aberrant intraocular findings; RL; glaucoma; RD; SD; inflammatory or cardiovascular conditions; SSI ≥ 7 1 Mo 130 eyes (65 patients)

M: 35

F: 30

67.8 ± 10.9 years
Tarek et al. (2021) OCC No NR

RD; glaucoma; uveitis;

amblyopia; SD; macular oedema; hard exudates; haemorrhages; SSI ≤ 7/10

1 Mo

G A: DM 30 eyes

G B: No DM 30 eyes

G A:

F: 76.60%

G B:

F: 73.30%

G A: 57.20 ± 4.09 years

G B:

54.50 ± 6.34 years

Zhu Z et al. (2023) PO No Age-related cataract DM; HTN; RD; glaucoma; ONH pathologies; RL; IOS; lack of cooperation for repeated measurements; SII ≤ 6 3 Mo 34 eyes (27 patients)

M:11

F:16

70.6 ± 14.0 years
Li et al. (2020) POS No Aged > 50 years Glaucoma; CD; RVD; previous IOS; OT; pre-existing OD affecting vision; SD 3 Mo

G A;

(SE) ≤ ‑6.0 D and (AL) ≥ 25 mm 24 eyes (21 patients)

G B: SE > ‑6.0 D and AL < 25 mm

31 eyes (23 patients)

G A: 9 M:9

F: 15

G B: M:11

F: 20 f

G A: 65.32 ± 6.01 years

G B: 67.66 ± 4.59 years

Curic et al. (2022) PS No

Senile cataract; OCTA SSI ≥ 30; AXL 20–25 mm; IOP 10–21 mmHg; BP ≥ 90/60 mmHg

and ≤ 140/90 mmHg

DM; CD; PEX; glaucoma; RD that could affect OCT and OCTA measurements; childhood, juvenile and traumatic cataract; IntraOp and /or postOp complications; unregulated HTN 6 Mo 95 eyes (95 patients)

M: 37

F: 58

73 years
Gawecki et al. (2022) RS No

Consent to participate in the study; history of uncomplicated CS; No RD;

SII ≥ 9/10 for OCTA

CE; PSC; SE ≥ -6D; AXL ≥ 26 mm 1 year 44 eyes (17 patients)

M:10

F: 7

NR
Yao et al. (2023) POCCS No Age ≥ 40 years; SE <  − 6 D; AXL < 26 mm; no OT; no history of IOS; no DME and DR treatment Glaucoma; uveitis; RD; vitreoretinal interface disorders; RVO; RAO 3 Mo

G A: DM: 22 eyes (22 patients)

G B: Control: 22 eyes (22 patients)

G A: M:13

F: 9

G B: M:12

F:10

G A:

65.1 ± 1.68 years

G B:

65.1 ± 1.68 years

Krizanovic et al. (2021) NR No

Uncomplicated senile cataract;

cataract PNS (1, 2, or 3); SII > 30; AXL (20–25 mm); IOP (10–21 mmHg); SYS: (90–140 mmHg);

DIA (60–90 mmHg)

CD; PEX; cataract other than uncomplicated senile; glaucoma; AMD; HR; PM;

DM; IntraOp and/or PostOp complications; poor SSI

3 Mo 55 eyes (55 patients)

M: 18

F:32

70 (65–76) years
Yang et al. (2022) OCS No NC; CC; no PP; no IOD; IOP < 21 mmHg Glaucoma; CD; RVD; previous IOS; SD; PM, VM; OCTA SSI < 6 (total score, 10); PostOp complications; high IOP; macular oedema; RD 3–6 Mo

G A: high myopia (AL ≥ 26.5 mm): 20 Patients

G B: control (22 < AL ≤ 24.5 mm):18 patients

G A: M:5

F: 15

G B:

M: 2

F:16

G A: 56 ± 6.42 years

G B: 57.53 ± 8.60 years

Feng et al. (2021) POS No

CS (T2DM);

IOP (10 mm and 21 mm Hg);

AXL (20.0 mm and 26.0 mm)

PDR; CSDME; anti-VEGF; PRP; OT; IOS; glaucoma; uveitis; OCT SSI < 5; severe cataracts; unstable fixation 3 Mo

G A: Diabetics 32 eyes (32 patients)

G B: Control 40 eyes (40 patients)

G A:

M: 31.25%

G B:

M: 32.5%

G A:

68.31 ± 9.42 years

G B: 71.60 ± 6.85 years

Svjaščenkova et al. (2023) PLS No Age ≥ 18 years; T2DM OT; MP 3 Mo

G A: DM con DME: 10 eyes

G B: DM sin DME: 22 eyes

G A:

M:1

F: 9

G B:

M: 5

F: 17

G A: 68.00 (63.25–74.50) years

G B: 71.00 (64.00–77.00) years

Özkan et al. (2022) PCSS No Age (40–70 years); clear ocular media; adequate pupillary dilation; fixation DM; HTN; IOS; SSI < 6; SE > 3D; AXL (22–24.5 mm); RD; glaucoma; regular medication; smoking 3 Mo 53 eyes of 53 patients

M: 25

F: 28

62.1 ± 7.2 years
Pilotto et al. (2019) PCSS No Cataract both eyes; SE(− 6 to + 6 D); SSI > 7 DM; HTA; amblyopia; strabismus; anisometropia > 3D; Dif AXL > 1.5 mm; IOS; uveitis; chronic open-angle glaucoma; RD 90 Dys 9 eyes of 9 patients

M: 6

F:3

71 ± 6 years
Kim et al. (2024) POCCS No Visually significant cataract Age < 18; poor SSI; DME; PDR; IOS; AXL > 26.5 mm; IOD; RD; complicate surgery 6 Mo

G DM NO DR: 60 eyes of 60 patients

G DM DR: 23 eyes of 23 patients

G NO DR:

M: 25 F: 35

G DR:

M: 8 F: 15

G NO RD: 69.5 ± 8.8

G RD: 69.6 ± 8.7

POS prospective observational study, RCSS retrospective cross-sectional study, PCSS prospective cross-sectional study, PCS prospective case series, PO prospective observational, PLS prospective longitudinal study, OCS observational cohort study, POCCS prospective observational case–control study, G group, RS retrospective study, POMC prospective observational monocentric control-group, OCC observational case–control. NR no reported, IOP intraocular pressure, Mo months, M male, F female, Dy day, Wk weeks, SSI signal strength index, NPDR non-proliferative diabetic retinopathy, DR diabetic retinopathy, SE spherical equivalent, AXL axial length, PNS pentacam nucleus staging, PDR proliferative diabetic retinopathy, CSDME clinically significant diabetic macular oedema, PRP panretinal photocoagulation, DM diabetes mellitus, DME diabetic macula oedema, T2DM type 2 diabetes mellitus, PP posterior polar cataract, PSC posterior subcapsular cataract, HTN hypertension, IVI intravitreal injection, RD retinal diseases, SD systemic disease, RL retinal laser, NC nuclear cataract, CC cortical cataract, OT ocular trauma, IntraOp intraoperative, PostOp post-operative CKD chronic kidney disease, SVD systemic vascular diseases, ONH optic nerve head, OD ocular diseases, IOD intraocular diseases, CD corneal diseases, PEX pseudoexfoliative syndrome, IOS intraocular surgery, SYS systolic blood pressure DIA diastolic blood pressure, MP macular pathologies, CE corneal oedema, BP blood pressure, RVD retinal vasculature diseases, RVO retinal vein occlusion, RAO retinal artery occlusion, AMD age-related macular degeneration, HR hypertensive retinopathy, PM pathological myopia, VM vascular maculopathy, CS cataract surgery.