. 2026 Jan 7;15(2):519–546. doi: 10.1007/s40123-025-01295-9

Table 2.

Analysis of clinical outcomes comparing the XEN45 implant as a standalone procedure versus its combination with cataract surgery (phacoemulsification) reported by the different meta-analyses

	XEN alone		XEN + phaco		Mean difference (95% CI)^a	p	XEN alone	XEN + phaco	Mean difference (95% CI)^a	p
Study	N	IOP lowering^a	N	IOP lowering^a	Mean difference (95% CI)^a	p	NOHM	NOHM	Mean difference (95% CI)^a	p
Wang et al. [21]	559	NP	475	NP	0.22 (0.05 to 0.40)	0.01	NP	NP	−0.20 (−0.46 to 0.06)	0.14
Chen et al. [24]	1074	−7.80 (−9.97 to −7.38)	659	−8.35 (−9.82 to −6.88)	NP	NP	−1.97 (−2.19 to −1.75	−1.86 (−2.11 to −1.60)	NP	NP
Yan et al. [25]	1314	NP	1160	NP	−0.01 (−0.09 to 0.08)	0.894	NP	NP	0.09 (−0.04 to 0.23)	0.672

N, number of eyes; 95% CI, 95% confidence interval; NOHM, number of ocular hypotensive medications; NP, not provided

^aMean (95% CI) intraocular pressure (IOP) lowering (mm Hg)