Table 2.
Wide-field sectoral RNFLT (S3–S12) in VF defect and VF unaffected regions of NAION eyes
| Characteristic Acute stage |
HC Matched region (n = 20) |
Acute VF Defect regiona (n = 22) |
Acute VF Unaffected regionb (n = 22) |
H/P | Defect vs. HC adj-P |
Unaffected vs. HC adj-P |
Defect vs. unaffected adj-P |
|---|---|---|---|---|---|---|---|
| pRNFLT | 131.00 [117.00, 143.00] | 339.00 [252.00, 379.00] | 205.00 [146.30, 253.00] |
38.81 < 0.0001**** |
0.02* | < 0.0001**** | 0.001** |
| GCIPLT | 76.82 [74.26, 78.93] | 74.34 [70.93, 80.55] | 73.31 [71.31, 79.04] |
8.58 0.014* |
0.09 | 0.02* | 0.99 |
| S3vsI3 | 33.34 [32.33, 38.56] | 33.90 [32.22, 39.25] | 34.25 [31.92, 36.18] |
0.05 0.98 |
0.99 | 0.85 | 0.84 |
| S6vsI6 | 43.17 [41.52, 45.35] | 49.14 [51.32, 54.60] | 51.95 [50.17, 54.35] |
31.61 < 0.0001**** |
< 0.0001**** | < 0.0001**** | 0.99 |
| S9vsI9 | 53.32 [52.39, 61.59] | 71.13 [58.11, 90.54] | 67.44 [61.45, 71.19] |
25.54 < 0.0001**** |
< 0.0001**** | 0.0002*** | 0.99 |
| S12vsI12 | 57.06 [51.86, 57.47] | 62.76 [60.79, 66.29] | 49.76 [42.06, 53.18] |
32.79 < 0.0001**** |
0.002** | 0.12 | < 0.0001**** |
| Characteristic Chronic stage |
HC Matched region (n = 20) |
Chronic VF Defect regiona (n = 27) |
Chronic VF Unaffected regionb (n = 27) |
H/P | Defect vs. HC adj-P |
Unaffected vs. HC adj-P |
Defect vs. unaffected adj-P |
|---|---|---|---|---|---|---|---|
| pRNFLT | 131.00 [117.00, 143.00] | 62.00 [55.00, 71.00] | 110.0 [90.00, 126.00] |
52.94 < 0.0001**** |
< 0.0001**** | 0.07 | < 0.0001**** |
| GCIPLT | 76.82 [74.26, 78.93] | 51.21 [42.27, 65.43] | 69.08 [47.49, 75.83] |
34.71 < 0.0001**** |
< 0.0001**** | 0.001** | 0.03* |
| S3vsI3 | 33.34 [32.33, 38.56] | 21.13 [17.98, 27.30] | 25.95 [19.07, 36.36] |
24.61 < 0.0001**** |
< 0.0001**** | 0.02* | 0.05 |
| S6vsI6 | 43.17 [41.52, 45.35] | 23.92 [18.06, 27.94] | 39.83 [23.02, 47.29] |
29.40 < 0.0001**** |
< 0.0001**** | 0.29 | 0.0004*** |
| S9vsI9 | 53.32 [52.39, 61.59] | 20.02 [18.00, 46.00] | 46.32 [37.40, 67.55] |
26.01 < 0.0001**** |
< 0.0001**** | 0.75 | 0.0003*** |
| S12vsI12 | 57.06 [51.86, 57.47] | 25.11 [21.31, 33.56] | 36.01 [29.45, 42.84] |
45.12 < 0.0001**** |
< 0.0001**** | 0.0002*** | 0.02* |
RNFLT sectors S3–S12 were analyzed [see Methods for definitions]
Values are median [IQR]. Kruskal–Wallis with Dunn’s post hoc test [Bonferroni correction]
P values < 0.05: *adj-P < 0.05, **adj-P < 0.01, ***adj-P < 0.001, ****adj-P < 0.0001
aVF defect = region with perimetric loss
bVF unaffected = region without perimetric loss