Table 4.
Unadjusted and adjusted association between red blood cell membrane fatty acids and indices and prevalent CKD.
| Unadjusted | Adjusted | |||||
|---|---|---|---|---|---|---|
| Odds ratio | 95% CI | p | Odds ratio | 95% CI | p | |
| Polyunsaturated fatty acids | ||||||
| 18:2n-6 (linoleic acid) | 0.91 | 0.81 to 1.01 | 0.086 | 0.81 | 0.67 to 0.99 | 0.035 |
| Interaction (18:2n-6*T2D) | – | – | – | 1.22 | 0.94 to 1.58 | 0.129 |
| Total n-6 PUFA | 0.91 | 0.84 to 0.98 | 0.014 | 0.86 | 0.76 to 0.98 | 0.025 |
| Interaction (total n-6 PUFA*T2D) | – | – | – | 1.19 | 0.99 to 1.42 | 0.064 |
| Total PUFA | 0.99 | 0.91 to 1.07 | 0.712 | 0.88 | 0.77 to 0.99 | 0.041 |
| Interaction (total PUFA*T2D) | – | – | – | 1.19 | 0.99 to 1.43 | 0.070 |
| Indices | ||||||
| Lipogenic index | 1.66 | 1.01 to 2.74 | 0.046 | 2.73 | 1.22 to 6.12 | 0.015 |
| Interaction (lipogenic index*T2D) | – | – | – | 0.42 | 0.14 to 1.27 | 0.124 |
Data represents odds ratio (OR), 95% confidence interval and p-value. Models adjusted for age, sex, waist circumference, HbA1c, TG, prevalent T2D, and the interaction between T2D and the various fatty acids. Only the individual fatty acids and indices that were significantly associated with CKD or had a significant interaction with the glycaemic categories are presented in the table. Normoglycaemia was used as reference. Abbreviations: lipogenic index, ratio of 16:0/18:2n-6; PUFA, polyunsaturated fatty acids.