Table 4.
Fold-change analysis of mRNA and protein expression of key molecules
| Comparison Group | Molecule | mRNA Fold Change | Protein Fold Change | Biological Interpretation |
|---|---|---|---|---|
| SAP+Homo vs SAP | SLC7A11 | 9.1 | 2.5 | Post-inhibition mRNA rebound with effective protein synthesis |
| GPX4 | 12.1 | 1.8 | Post-inhibition mRNA rebound with effective protein synthesis | |
| shRNA-circDNMT3B+SAP+Homo vs shRNA-NC+SAP+Homo | SLC7A11 | 0.65 | 0.6 | Synchronous reduction upon loss of upstream regulation |
| GPX4 | 0.2 | 0.56 | Synchronous reduction upon loss of upstream regulation |