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. 2025 Dec 23;136(4):e196536. doi: 10.1172/JCI196536

Figure 2. Blood and colon T cells exhibit distinct population abundances and transcriptomic profiles.

Figure 2

(A) UMAP visualization of combined T cell clusters 1–20. (B) UMAP visualization of unstimulated T cells from the blood and colon, with the different compartments shown separately. (C) Dot plot comparing expression for selected differentially expressed transcription factor and surface markers between unstimulated blood and colon CD4+ T cells. (D) Abundance of cells within individual T cell clusters in each compartment, as a fraction of all cells in the compartment. Data from colon cells are shown in blue; data from blood cells are shown in red. (E and F) Dot plots showing expression of transcription factor and surface markers in unstimulated colon-derived (E) and blood-derived (F) T cells within each cluster.