Table 3.
PrEP (pre-exposure prophylaxis) Epidemiology, Modeling, and Surveillance (PREMISE) anticipated timeline and research activities across the 5-year grant perioda.
| Activities | Year | Data source | Planned analyses | ||||||||||||||||||||||||
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1 | 2 | 3 | 4 | 5 |
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<> | <> | <> | <> | <> | <> | <> | <> | <> | <> |
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| Objective 1: Longitudinal PrEPb provision analyses | |||||||||||||||||||||||||||
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Descriptive analyses of PrEP modality (TDFc, TAFd, and LAIe) by race | ✓ | ✓ |
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National PrEP database | Descriptive and exploratory longitudinal cohort | ||||||||||||||
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10-year longitudinal patterns of PrEP use |
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✓ | ✓ |
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National PrEP database | Descriptive and exploratory longitudinal cohort | ||||||||||||||
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Analyses of LAI-PrEP users and retention in care |
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✓ | ✓ |
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National PrEP database | Descriptive and exploratory longitudinal cohort | ||||||||||||||
| Objective 2: Quasi-experiments of PrEP policies and programs | |||||||||||||||||||||||||||
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Develop program and policy dataset | ✓ | ✓ | ✓ |
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Health jurisdiction surveys, public records, and legal extraction data | DIDf or DDDg | ||||||||||||||
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Conduct quasi-experiments on PrEP initiation: EHEh, PrEP DAPi, Medicaid Expansion, and pharmacist-provided PrEP |
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✓ | ✓ | ✓ | ✓ | ✓ |
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National PrEP database, program, and policy dataset | DID or DDD | ||||||||||||||
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Assess policy effects on PrEP initiation: PrEP DAP and Medicaid |
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✓ | ✓ | ✓ | ✓ |
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National PrEP database, program, and policy dataset | DID or DDD | ||||||||||||||
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Assess program and policy effects on retention in PrEP care |
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✓ | ✓ | ✓ | ✓ | ✓ |
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National PrEP database, program, and policy dataset | DID or DDD | ||||||||||||||
| Objective 3: Model epidemic impact and cost-effectiveness analyses | |||||||||||||||||||||||||||
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Modeling program and policy long-term impact |
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✓ | ✓ | ✓ | ✓ |
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National PrEP database, program, and policy dataset | Mathematical modeling | ||||||||||||||
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Cost-effectiveness analyses |
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✓ | ✓ | ✓ | ✓ |
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National PrEP database, program, and policy dataset | Mathematical modeling | ||||||||||||||
| Dissemination phase | |||||||||||||||||||||||||||
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AIDSVu blog posts and website infographics |
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✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | National PrEP database, program, and policy dataset | N/Aj | ||||||||||||||
aThis table outlines the planned research activities for the 5-year grant period, detailing the research objectives, corresponding analyses, required data sources, and the anticipated year in which each activity will be conducted.
bPrEP: pre-exposure prophylaxis.
cTDF: tenofovir disoproxil fumarate.
dTAF: tenofovir alafenamide fumarate.
eLAI: long-acting injectable.
fDID: difference-in-differences.
gDDD: difference-in-difference-in-differences.
hEHE: Ending the HIV Epidemic.
iPrEP DAP: Pre-Exposure Prophylaxis Drug Assistance Program.
jN/A: not applicable.