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Localization of the missense mutations causing LAD, along the CD18 subunit: most of the mutations causing a single amino-acid substitution are clustered in the NH2 domain 250 residues that are highly conserved among the β integrins (β1–β8). A Greek letter indicates each point mutation. Asterisks (*) indicate potential hot spot mutations 1, 2, 3, 4 are the cystein rich repeats, TM = transmembrane domain, CD = cytoplasmic domain.
