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. 2026 Feb 12;14:e20686. doi: 10.7717/peerj.20686

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©2026 Lu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.

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(A) Positively enriched pathways in tumors with high SLC7A11 expression. (B) Negatively enriched pathways in tumors with SLC7A11 expression. (C) Heatmap of genes co-expressed with SLC7A11 that are related to ferroptosis. (D) Heatmap of genes co-expressed with SLC7A11 that are involved in NRF2 signaling. (E) PPI networks of ferroptosis-related gene sets (F) PPI networks of NRF2-related gene sets. NES, normalized enrichment score; FDR, false discovery rate.