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Factor (F)VIII concentration-response for half maximal effective concentration (EC50) estimation. Fitted EC50 values for FVIII concentration in the thrombin generation assay (TGA) response using various trigger concentrations of activated FXI (FXIa), tissue factor (TF), and 1 pM TF + FXIa. Axes scales are logarithmic (log10). ETP, endogenous thrombin potential; IU, International Units; mU, milliunits; Peak, thrombin peak; VI, velocity index.
