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Assay range for factor (F)VIII bioequivalence of denecimig. The assay range (gray shaded area) of FVIII concentrations in the thrombin generation assay (TGA) response using various trigger concentrations of tissue factor (TF), activated FXI (FXIa), and 1 pM TF + FXIa. Axes scales are logarithmic (log10); gray background: assay range. ETP, endogenous thrombin potential; IU, International Units; mU, milliunits; Peak, thrombin peak; VI, velocity index.
