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Effect of thrombin generation assay (TGA) parameters on factor (F)VIII bioequivalence of denecimig under different trigger conditions. FVIII bioequivalence at 5 μg/mL of denecimig in TGA response using various trigger concentrations of tissue factor (TF), activated FXI (FXIa), and 1 pM TF + FXIa. Axes scales are logarithmic (log10). ETP, endogenous thrombin potential; IU, International Units; mU, milliunits; Peak, thrombin peak; VI, velocity index.
