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. 2026 Jan 2;10(1):103333. doi: 10.1016/j.rpth.2025.103333

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© 2026 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Factor (F)VIII bioequivalence of denecimig with the activated FIX (FIXa) trigger. (A) Peak thrombin generation-based FVIII bioequivalence of denecimig with the FIXa trigger. Gray shaded area: assay range; colored markers: FVIII equivalence (FVIIIeq) of FVIII measurements; colored lines: expected FVIIIeq of FVIII measurements; black markers: FVIIIeq of denecimig; black line: predicted FVIIIeq of 5 μg/mL denecimig. (B) Thrombin generation assay parameters for denecimig FVIII bioequivalence with the FIXa trigger. The x-axis scale is logarithmic (log₁₀). ETP, endogenous thrombin potential; IU, International Units; Peak, thrombin peak; VI, velocity index.