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Factor (F)VIII bioequivalence of denecimig and the emicizumab sequence-identical analog (Emi-SIA). FVIII bioequivalence of 5 μg/mL denecimig and 50 μg/mL Emi-SIA in the thrombin generation assay response using various trigger concentrations of tissue factor (TF), activated FXI (FXIa), and 1 pM TF + FXI. Axes scales are logarithmic (log10). ETP, endogenous thrombin potential; FIXa, activated factor IX; IU, International Units; mU, milliunits; Peak, thrombin peak; VI, velocity index.
