Table 2. IC₅₀ values of colchicine and active derivatives against A549, HepG2, and L929 cells (mean ± SD, n = 3).

Compounds	IC50 values (nM)			Selectivity index (SI)
	A549	HepG2	L929	A549	HepG2
1	39.6 ± 1.9	46.6 ± 5.8	425.7 ± 36.3	11	9
B3	11.2 ± 1.3	21.5 ± 0.8	730.1 ± 60.2	65	34
B6	9.4 ± 1.5	16.3 ± 1.9	441.8 ± 43.8	47	27
B7	4.0 ± 0.6	8.1 ± 0.8	446.1 ± 14.4	112	55
B8	7.3 ± 1.6	17.0 ± 1.7	376.3 ± 26.6	52	22