Table 2.
Chromosome 3p characteristics are linked to recurrence and metastatic disease
| Characteristic | Overall N = 1161 | No recurrence N = 431 | Recurrence N = 351 | Metastatic N = 381 | p-value2 |
|---|---|---|---|---|---|
| Loss | 102 (88%) | 39 (91%) | 32 (91%) | 31 (82%) | 0.4 |
| Methylation | 81 (70%) | 24 (56%) | 27 (77%) | 30 (79%) | 0.041 |
| Both | 72 (62%) | 23 (53%) | 24 (69%) | 25 (66%) | 0.3 |
Chromosome 3p (chr3p) regions included in differentially methylated regions (n = 2717), ranging from chr3p position 219,601 to 88,395,600 for 300 bp methylated regions and the entire chr3p region, ranging from chr3p position 0 to 90,900,000 for 1 Mb genomic bins. Loss is defined as median log2ratio < − 0.1 across chr3p. Methylation is defined as median nrpm > 0.1 across chr3p regions. Metastatic = synchronous metastatic. Both = loss and methylation at chr3p regions
1n (%)
2Fisher's exact test; Pearson's Chi-squared test