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. 2026 Feb 2;13:1744053. doi: 10.3389/fvets.2026.1744053

Table 5.

Examples of ML studies and the potential of digital twin to develop the results outcomes.

Animal species Study Studied variable Marker References DT upgrading potential
Dairy cattle Developing an artificial neural network for the early prediction of subclinical ketosis during lactation. Subclinical Ketosis 50,025 and 10,005 SNPs (185) Predict the effect on lactation performance and yield, and forecast culled animals.
Beef cattle (Nellore) Utilizing machine learning to find small subsets of biologically significant genes for classifying animals into High Feed Efficiency and Low Feed Efficiency categories. Feed efficiency 16,423 genes (186) Rearranging this subset or investigating new gene subsets to predict their effect on the traits.
Goat Efficiently oversee the health and welfare of their goats, thereby enhancing living circumstances and augmenting dairy output. Animal behavior Goat activity (187) Mimic population behavior changes and track their effect on herd performance.
Dairy cattle Image processing algorithms and the YOLOv8 model facilitate the real-time, non-invasive monitoring of feeding periods. Feed utilization efficiency Feeding pattern (188) Simulate different feeding strategies and forecast productivity and economics.
Cattle and Buffalo Forecasting lumpy skin disease infection LSD occurrence Meteorological and geological attributes (189) Stimulate assessment of infection virulence and its effects on productivity, and estimate potential economic losses in specific regions.
(Sheep) (Harnai) Predicting live weight at the post-weaning period. Growth performance Body biometric parameters and sex factor. (190) Predicting the Economics of the Production
Pigs Infection prediction in swine populations, both seven and 30 days in advance Infection Outbreak Nearby farm density, historical test rates, piglet inventory, feed consumption during gestation, and wind speed and direction. (95) Simulate the evaluation for disease prevention and mitigation strategies.
Cattle 16S rRNA sequencing and machine learning methodologies identified a dozen species as taxonomic indicators for distinguishing infection. The Mycobacterium avium disease state. Fecal microbiota (191) Investigate the effects of microbial dysbiosis on pathogenic microbes. The Gut-host interaction
Chicken Investigate antimicrobial resistance profiles across multiple chicken farms and abattoirs. Antimicrobial resistance genes E. coli (192) Forecast the intensity of ARGs under different environmental conditions and correlate ARGs with different microbiomes.
In-vitro fermentation Prediction of Methane Production from in vitro Ruminal Fermentation Methane Volatile fatty acids (193) Introducing a cross-species Virtual rumen fermentation model
Water-Deer
Water Buffalo
Sheep Buffalo
Combined network analysis and interpretable machine learning reveal Environmental adaptability Microbial genomes (194) Predicting which pathogen species are most likely to emerge in the future
Wild-Livestock ML demonstrates one approach to planning for and preventing disease emergence in livestock. Pathogen-host associations at the wildlife–livestock interface Bacterial association (195)