Table 2.
Fine-Gray Competing Risk Regression Analysis of Factors Associated with II–IV0 aGVHD
| Characteristic | Univariable | Multivariable | ||
|---|---|---|---|---|
| sHR (95% CI) | p-value | sHR (95% CI) | p-value | |
| MDSCs(units/kg) | ||||
| ≤33.3 | reference | reference | ||
| ＞33.3 | 0.38 (0.19 -0.75) | 0.006 | 0.71 (0.21 -2.46) | 0.590 |
| M-MDSC (units/kg) | ||||
| ≤7 | reference | reference | ||
| ＞7 | 0.55 (0.29 -1.05) | 0.071 | 0.84 (0.31 -2.31) | 0.730 |
| PMN-MDSCs(units/kg) | ||||
| ≤17.5 | reference | reference | ||
| ＞17.5 | 0.43 (0.22 -0.85) | 0.014 | 0.25 (0.07 -0.88) | 0.039 |
| LOX1+PMN-MDSCs(units/kg) | ||||
| ≤2.5 | reference | reference | ||
| ＞2.5 | 0.56 (0.29 -1.09) | 0.086 | 1.16 (0.46 -2.92) | 0.750 |
| MDSCs (%) | ||||
| ≤5 | reference | reference | ||
| ＞5 | 0.53 (0.28 -1.03) | 0.060 | 0.92 (0.36 -2.35) | 0.850 |
| M-MDSCs (%) | ||||
| ≤1 | reference | reference | ||
| ＞1 | 0.54 (0.27 -1.04) | 0.066 | 0.96 (0.31 -2.96) | 0.940 |
| PMN-MDSCs (%) | ||||
| ≤3 | reference | |||
| ＞3 | 0.64 (0.34 -1.24) | 0.187 | ||
| LOX+PMN-MDSCs (%) | ||||
| ≤16 | reference | |||
| ＞16 | 1.53 (0.80 -2.94) | 0.198 | ||
| MDSCs absolute count,/μL | ||||
| ≤14000 | reference | reference | ||
| ＞14000 | 0.47 (0.24 -0.92) | 0.027 | 0.92 (0.21 -4.11) | 0.910 |
| M-MDSCs absolute count,/μL | ||||
| ≤2600 | reference | reference | ||
| ＞2600 | 0.42 (0.21 -0.82) | 0.012 | 0.28 (0.10 -0.78) | 0.015 |
| PMN-MDSCs absolute count,/μL | ||||
| ≤8000 | reference | reference | ||
| ＞8000 | 0.55 (0.29 -1.06) | 0.074 | 0.59 (0.30 -1.21) | 0.150 |
| LOX1+PMN-MDSCs absolute count,/μL | ||||
| ≤900 | reference | |||
| ＞900 | 0.83 (0.44 -1.57) | 0.571 | ||
| Gender | ||||
| Female | reference | |||
| Male | 0.59 (0.30 -1.15) | 0.120 | ||
| Age,years | ||||
| ≤18 | reference | reference | ||
| ＞18 | 0.48 (0.25 -0.93) | 0.029 | 0.54 (0.26 -1.15) | 0.110 |
| 2nd HSCT | ||||
| No | reference | |||
| Yes | 0.59 (0.18 -1.93) | 0.380 | ||
| Disease status pre-HSCT | ||||
| CR | reference | |||
| PR/NR | 0.64 (0.25 -1.66) | 0.360 | ||
| HSCT type | ||||
| Related donors | reference | reference | ||
| Unrelated donors | 0.42 (0.13 -1.34) | 0.140 | 0.64 (0.13 -3.04) | 0.570 |
| Donor type | ||||
| HID | reference | reference | ||
| MSD | 0.40 (0.13 -1.24) | 0.110 | 0.33 (0.09 -1.27) | 0.110 |
| MNC ×108/kg | ||||
| ≤6 | reference | |||
| ＞6 | 1.30 (0.68 -2.49) | 0.420 | ||
| CD34 ×106/kg | ||||
| ≤4 | reference | reference | ||
| ＞4 | 1.30 (0.68 -2.49) | 0.091 | 0.70 (0.33 -1.48) | 0.350 |
sHR subdistribution hazard ratio