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. 2005 Dec;25(23):10329–10337. doi: 10.1128/MCB.25.23.10329-10337.2005

FIG. 2.

FIG. 2.

Lung and kidney abnormalities occur in E18.5 Scythe−/− embryos. (A to D) Compared to the WT (+/+) (A and B), abnormal lung development was present in Scythe mutants (−/−) (C and D). Lungs were analyzed at the saccular stage of development. In the WT, bronchial tree formation in the lungs was complete (arrow) and normal alveolization was observed (*) (B). Lungs were smaller and markedly less developed in Scythe−/− embryos (C and D), with decreased branching of terminal bronchioles (arrow) and nearly complete lack of alveolization (*). (Inset panels B and D show higher magnifications of panels A and C, respectively). (E to J) Abnormalities observed in E18.5 Scythe−/− kidneys. Scythe mutants showed smaller kidneys (G) or no kidney (I), with enlarged glomeruli (H, arrow) and dilated tubules (H, asterisk) compared to those of the WT (E and F, same symbols). Sections were stained with hematoxylin and eosin. Aside from kidney defects in Scythe−/− animals, the remainder of the urogenital system was normal (J). a, adrenal gland; k, kidney; b, bladder.