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Scythe loss affects neural development. (A) Excencephaly (arrows) was observed for Scythe−/− embryos at E14.5. (B) Improper expansion of the midbrain and the hindbrain (arrows) was observed for these E14.5 embryos, as indicated by Nissl staining. (C) Edema was also present. (D and E) Tuj1 and Ki67 staining showed an expanded ventricular zone at E12.5 in Scythe−/− embryos (D) and an increase in proliferating cells in the Scythe−/− neopallial cortex at E14.5 and midbrain at E12.5 (E).
