TABLE 1.
Embryonic survival in Scythe-null mice
| Time point | No. of mice of Scythe genotypea
|
No. of mice with:
|
|||
|---|---|---|---|---|---|
| +/+ | +/− | −/− | Resorptions | Exencephaly | |
| E12.5 | 8 | 12 | 5 | 8 | |
| E13.5 | 92 | 193 | 104 | 45 | 7 |
| E14.5 | 37 | 95 | 44 | 18 | 10 |
| E15.5 | 7 | 20 | 6 | 3 | 2 |
| E16.5 | 13 | 9 | 11 | 5 | |
| E17.5 | 6 | 11 | 8 | 2 | |
| E18.5 | 19 | 52 | 13 | 3 | 1 |
| E19.5 | 2 | 1 | 1 | ||
| >P0 | 313 | 518 | (31)b | ||
a
Genotyping of mice was determined by PCR analysis. The expected ratio of Scythe+/+ to Scythe+/− to Scythe−/− mice was 1:2:1.
b
Number in parentheses indicates dead mice. No Scythe-null mice were found alive.