TABLE 2.
Hif1α+/− Hif2α+/− × Hif1α+/− Hif2α+/− matings
| Hif1α | Hif2α | No. of live progeny expected | No. of live progeny observeda | No. expected at E9.5c | No. observed at E9.5 |
|---|---|---|---|---|---|
| +/+ | +/+ | 12.5 | 54 | 3.5 | 4 |
| +/+ | −/− | 12.5 | 0 | 3.5 | 3 |
| −/− | +/+ | 12.5 | 0 | 3.5 | 4 |
| −/− | −/− | 12.5 | 0 | 3.5 | 3 |
| +/+ | +/− | 25 | 43 | 7 | 9 |
| +/− | +/+ | 25 | 61 | 7 | 7 |
| +/− | +/− | 50 | 42 | 14 | 18 |
| +/− | −/− | 25 | 0 | 7 | 4 |
| −/− | +/− | 25 | 0 | 7 | 5 |
| Modified ratiosb | |||||
| +/+ | +/+ | 22.25 | 54 | ||
| +/+ | −/− | 0 | 0 | ||
| −/− | +/+ | 0 | 0 | ||
| −/− | −/− | 0 | 0 | ||
| +/+ | +/− | 42.7 | 43 | ||
| +/− | +/+ | 42.7 | 61 | ||
| +/− | +/− | 89 | 42 | ||
| +/− | −/− | 0 | 0 | ||
| −/− | +/− | 0 | 0 |
a
n = 200 for live progeny.
b
Mendelian ratios were modified to account for the embryonic lethality of five of the genotypes.
c
n = 56 for timed matings at embryonic day 9.5.