Apoptosis in wild-type (WT) and DKO embryos. The left panels are HE staining, and the right panels are TUNEL staining. In the wild type, very few apoptotic cells can be seen in the neuroepithelium, but there are many in DKO neuroepithelium (arrowheads indicate apoptotic cells). (A to D) E10.5; (E to H) E9.5. Magnification for panels A and B, ×40; for panels C to F, ×200.