TABLE 1.
Hemodynamic measurements of control Mck-cre; Aif+/Y and mutant Mck-cre; Aifflox/Y heartsa
| Parameter | Mean ± SEM
|
|
|---|---|---|
| Mck-cre; Aif+/Y (n = 6) | Mck-cre; Aifflox/Y (n = 6) | |
| Heart rate (bpm) | 536 ± 4 | 566 ± 11 |
| Systolic BP (mm Hg) | 111.8 ± 1.6 | 87.7 ± 3.2 |
| Diastolic BP (mm Hg) | 72.4 ± 1.3 | 67.6 ± 2.2 |
| Mean arterial BP (mm Hg) | 85.6 ± 1.0 | 74.3 ± 2.4 |
| LVS BP (mm Hg) | 110.9 ± 2.1 | 86.3 ± 3.1 |
| LVED BP (mm Hg) | 3.5 ± 0.6 | 16.2 ± 0.8 |
| +dP/dtmax (mm Hg/s) | 11,359 ± 405 | 4,075 ± 344 |
| −dP/dtmin (mm Hg/s) | 10,983 ± 458 | 3,457 ± 298 |
a
Hemodynamic measurements for 8-week-old mice. bpm, beats per minute; BP, blood pressure; LVS, left ventricular systolic; LVED, left ventricular end diastolic; +dp/dtmax, maximum first derivative of the change in left ventricular pressure; −dP/dtmin, minimum first derivative of the change in left ventricular pressure. P < 0.05 between genotypes for all comparisons (Student’s t test).