FIG. 1.

Thiamine biosynthesis and salvage pathway of Bacillus subtilis. B. subtilis thi genes were previously identified by genetic, biochemical, and/or in silico evidence (1, 19, 25, 26, 29); in some cases, their original y gene designation is listed. E. coli intermediates or genes not present in B. subtilis but with similar functions are given in parentheses (1). Abbreviations are in brackets. The thiamine-TMP-TPP salvage pathway is shown in a shaded box. See the text for details. Question marks indicate possible unknown genes involved in the thiamine biosynthesis and salvage pathway (15, 19). The organization of Bacillus thiamine biosynthesis genes is shown on the right.