Table 2.

Age at PD onset between LRRK2 p.A419V PD carriers and non-carriers in the GP2 cohort

	Total			AJ			CAS			CAH			EUR			EAS
	p.A419V carrier	non-carrier	p value	p.A419V carrier	non-carrier	p value	p.A419V carrier	non-carrier	p value	p.A419V carrier	non-carrier	p value	p.A419V carrier	non-carrier	p value	p.A419V carrier	non-carrier	p value
AAO, N	100	15,189	2.526e–09***	1	1338		10	449	0.035*	3	405	0.520	13	10,705	0.357	73	2292	0.028*
mean ± SD	50.29 ± 12.70	57.95 ± 12.40		45	62.37 ± 11.59		44.8 ± 11.85	52.8 ± 11.75		47.33 ± 17.67	53.93 ± 13.95		55.46 ± 12.93	58.74 ± 12.03		50.32 ± 12.56	53.41 ± 12.65
median [IQR]	49 [20]	59 [18]		45	64 [16]		48.5 [16]	54 [16]		56 [16]	55 [19]		55 [16]	60 [16 .4]		49 [20]	52 [18]
FHX, n/N	14/79	4251/16,848	0.142	0/0	484/1572	NA	1/11	58/505	1	2/4	100/504	0.181	3/11	2953/11,610	0.356	8/53	656/2657	0.291
(%)	17.72	25.23		0	30.79		9.09	11.49		50	19.84		27.27	25.43		15.09	24.69
Male, n/N	57/141	11,922/19,675	0.000***	1/1	1125/1705	1	1/13	300/648	0.008**	4/14	365/630	0.052	15/33	9528/15,288	0.041*	37/81	1729/3109	0.087
(%)	40.43	60.59		100	65.98		7.69	46.3		28.57	57.94		45.45	62.32		45.68	55.61

Mann–Whitney U test was used for comparing age at onset difference between carrier and non-carrier groups. Fisher’s test was used for family history and sex comparison between carrier and non-carrier groups.

n number of individuals with available information, N total number of individuals, IQR inter quartile range, FHX family history of PD, SD standard deviation, AAO age at onset, AJ Ashkenazi Jewish, CAH Complex Admixture History, CAS Central Asian, EAS East Asian, EUR European.

*P ≤ 0.05; ** P ≤ 0.01; *** P ≤ 0.001