Figure 2.
Influence of inhaled tolafentrine on hemodynamics in monocrotaline – induced pulmonary arterial hypertension. Right ventricular systolic pressure (RVSP, in mmHg), systemic arterial pressure (SAP, in mmHg), cardiac index (CI, in ml min-1 100 g body weight-1) and total pulmonary resistance index (PRI, in mmHg min ml-1 100 g body weight-1) are given. Tolafentrine was applied by repetitive inhalations from day 28 to day 42. All values are given as mean ± SEM. *, p < 0.05 versus control; †, p < 0.05 versus MCT[28d]; ‡, p < 0.05 versus MCT[42d].