Table 3.

Definitions of the parameters.

Parameters
Gb [mM]	basal glycemia
Ib [pM]	basal insulinemia
Txg [mM / min]	maximal insulin-independent rate constant for glucose tissue uptake
KxgI [min-1/pM]	insulin-dependent apparent first-order rate constant for glucose tissue uptake at insulinemia I
Kxi [min-1]	apparent first-order rate constant for insulin removal from plasma
TiG [pM/min/mM]	apparent zero-order net insulin synthesis rate at unit glycemia (after liver first-pass effect)
Tixb [pmol/min/kgBW]	basal insulin infusion rate, which is given by the measured value of Tix at time zero according to [18]
Tghmax [mmol/min/kgBW]	maximal Hepatic Glucose Output at zero glycemia, zero insulinemia
Tghb [mmol/min/kgBW]	basal value of Tgh
Vg [L/kgBW]	volume of distribution for glucose
Vi [L/kgBW]	volume of distribution for insulin
α [#]	time constant for the insulin delay kernel ω(·)
τg [min]	discrete (distributional) delay of the change in glycemia following glucose infusion
λ [mM-1pM-1]	rate constant for Hepatic Glucose Output decrease with increase of glycemia and insulinemia
ρ [#]	average delay of insulin effect