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. 2026 Feb 3;15:e87961. doi: 10.2196/87961

Table 2.

Intervention program.

Group Intervention components Frequency or duration Key operational parameters Safety monitoring
Acupoint massage Stimulation of Zhongwan (CV-12), Tianshu (bilateral; ST-25), Zusanli (bilateral; ST-36), and Neiguan (bilateral; PC-6) Twice daily (2 minutes per acupoint)

  • Technique: rotatory kneading+vertical pressing

  • Pressure: ≤0.5 kg (aged 2-5 y) and ≤1 kg (aged 6-12 y)

  • Sequence: CV-12→ST-25→ST-36→PC-6

  • Preprocedure wound assessment

  • Real-time tolerance monitoring

  • Skin response check

  • Emergency stop for vomiting or pain
Mirabilite application Periumbilical paste application (xiphoid process to pubic symphysis) Twice daily (1 hour, with a 5-minute margin on either side)

  • Allergy test

  • Preparation: 1:1 mirabilite: water (36 °C-38 °C)

  • Thickness: 0.5 cm uniform layer

  • Fixation: hypoallergenic tape

  • Constant temperature heating pack

  • Preapplication skin test

  • Temperature monitoring (36 °C-38 °C; ΔT≤1 °C)

  • Visual inspection

  • Discontinuation for erythema or blisters
Combination group Both interventions Massage: 2 per day; mirabilite: 2 per day; minimum interval: 60 minutes

  • Sequence: massage→mirabilite (preferred)

  • Prohibited: massage within 1 hour after mirabilite application

  • Separate documentation for both

  • Combined monitoring of both interventions