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. 2026 Jan 22;16:1701694. doi: 10.3389/fphar.2025.1701694

FIGURE 7.

Heatmap and scatter plots. Panel A shows a heatmap of correlations between gut microbiota and various samples, with colors ranging from red (positive correlation) to blue (negative correlation). Panels B through F display scatter plots illustrating correlations between different bacterial groups and fecal energy loss, labeled with rho and p-values, distinct groups marked in colors (SD, PCOS, PCOS+SZA). Statistical significance and trend lines are included.

Associations between gut microbial species and circulating metabolites. Spearman’s rank correlation between 33 gut microbial species and 13 metabolites in the SD, PCOS, and PCOS+SZ-A groups is presented (A). Red panes represent positive correlations between bacterial species and metabolites, and blue panes represent negative correlations between bacterial species and metabolites (*p < 0.05; **p < 0.01; ***p < 0.001). Scatter plot indicates the Person’s correlation coefficient with statistical significance (p < 0.05) between Eubacterium_Coprostanogenes (B), Lachnospiraceae_NK4B4 (C), Eubacterium_ruminantium (D), Ruminococcus_UGG_004 (E) or Allobaculum (F) and serum Fenoldopam levels in all the three groups. n = 5 rats in SD group, n = 6 rats in other groups, values are presented as means ± SD.