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. 2026 Feb 5;17:1749728. doi: 10.3389/fphar.2026.1749728

FIGURE 2.

Scientific figure with three panels. Panel A diagrams the experimental timeline for rats receiving vaginal smears, honey treatment, and sample collection. Panel B shows vaginal smear microscopic images comparing cell types across estrous cycle stages in sham and model groups, each labeled with a two-hundred micrometer scale bar. Panel C is a line graph displaying body weight over thirty-three days for six groups, with the model group showing the highest weight gain.

Validation of the PMS rat model. (A) Experimental timeline and validation of the model. (B) Representative vaginal smear cytology of a single rat from the Sham group across different estrous phases (H&E staining, 100×, 200 μm scale bar). (C) Body weight curves of rats in each group during the experimental observation period (n = 5).